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Applikon ez2-Control

The Applikon ez2-Control bioprocess controller
The Applikon ez2-Control with bioprocess HMI
The Applikon ez2-Control to control and optimize bioprocesses

Applikon ez2-Control

The ez2-Control is there to simplify your bioprocess. Its multiple software innovations make it easy to control your bioreactor. The web-interface for the ez2-Control provides a clear overview of the parameters of your bioprocess, putting the attention right where it’s needed. 


Easy to control your bioreactor

  • Up to 6 Mass Flow Controllers
  • Less maintenance due to brushless motor
  • Powerful software features to simplify and optimize bioprocesses

Advanced user management enables you to create up to 21 users on 3 authorization levels. Back-ups, copies and predefined settings of configurations can simply be shared via USB. Extra flexibility is brought by additional analog and digital inputs / outputs.

The brushless motor requires virtually no maintenance, which saves you costs in the long term. It contains only one cable for the motor power and feedback and includes a motor controller. The ez2-Control comes with a motor support at the side of the device for easy operation.

Features & Specifications

Full control

Easily set, control and adapt your parameters, including pH, temperature, dissolved oxygen, agitation, foam, and level to optimize the bioprocess. It has total gas flow control to reduce shear stress for cell cultivations.

It is based on the same familiar Getinge Applikon control platform as the other controllers.

Advanced control strategies

The ez2-Control comes with selectable autotuning adaptive PID control for accurate control when process conditions change during the culture.

It has extended liquid additions options via (up to) 4 variable speed pumps. And it comes with enhanced gas addition strategies via (up to) 6 mass flow controllers.

Easy operation

The built-in web server allows the ez2-Control to be operated by any computer with a web browser: Microsoft Edge, Mozilla Firefox, Apple Safari or Google Chrome. Wireless devices like iPad, iPhone or Android tablets or phones can also be used to operate an ez2-Control.
Via the built-in web server enhanced parallel processing is accessible which allows the user to control multiple bioreactors in parallel.

The remote desktop support gives you access whenever and where ever you want.


pH Sensor Traditional electrochemical or Single-use
Measurement range: 0-14 pH, accuracy 0,01 pH
DO sensor Traditional Polarographic, LumiSens or Single-use
Measurement Range: 0-100% saturation, accuracy 0,1%
Redox Traditional electrochemical
Range 2000 mV, accuracy +/- 1 mV, resolution 1 mV
Temperature Pt-100
Measurement Range: 0-150 °C accuracy 0,1°C
Foam/level Resistive based measurement
Weight Balances
Optional Biomass (Capacitance or optical density), offgas measurements, pressure
Additional I/O Up to 8 Analog in and 4 Analog out
Up to 8 Digital In and 8 Digital out
Gas Up to 6 MFC’s with solenoid valves or
Up to 4 rotameters with solenoid valves
Liquids Up to 3 internal fixed speed pumps
Up to 4 external variable speed pumps
Stirring 0-2000 rpm with feedback, accuracy 0,1% FS
Temperature Heating blanket or internal Thermocircuilator
Cooling with cold water water valve
Control hardware platform Applikon proprietary
Control software platform Applikon Firmware
Certifications CE certified, GAMP compliant
21 CFR part 11 compatible Yes
Communication & SCADA Lucullus PIMS, DeltaV
  Applikon OPC server available


The Applikon ez2-Control is ideal for the following applications:

  • Microbial and cell cultures
  • Batch, Fed-Batch, Perfusion, and Continuous cultivation
  • Autoclavable bioreactors up to 20 liter volume
  • Single-use bioreactors
  • Steam-in-place bioreactors

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