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Applikon in-Control

The Applikon in-Control bioprocess controller
The Applikon in-Control controller with bioprocess HMI
The Applikon in-Control bioprocess controller

Applikon in-Control

The in-Control is a process controller for laboratory scale bioreactors, offering high level control on a small footprint. This modular system allows you to create the most optimal set-up as you can add any extra inputs or outputs. You are in control. 


Simply Powerful

  • Increased flexibility by extra inputs and outputs
  • Easy operation through touch screen interface and through web browsers
  • Enhanced gas addition strategies via Mass Flow Controllers
  • Reduce footprint by small size controller
  • Replacement of ADI biocontrollers

The in-Control can be used to increase the capabilities of your bioreactor system with a minimal investment and no downtime for your process. The controller can be used for both cell culture and microbial cultures.

The in-Control is easy to operate via an intuitive human interface in combination with a color touchscreen. Due to its small size and simple operation, this system is very well suited to control single-use mixing systems where agitation, temperature, level, and pH need to be measured and/or controlled. The system is a drop-in-replacement for the older ADI 1010 Bio Controller and ADI 1030 Bio Controller.

Features & Specifications

Full control

Easily set, control and adapt your parameters, including pH, temperature, dissolved oxygen, agitation, foam, and level to optimize the bioprocess. It has an USB connection for optional biomass or fluorophor pH and DO sensors and balances.

It is based on the same familiar Getinge Applikon control platform as the other controllers.

Adaptive PID

The in-Control comes with selectable autotuning adaptive PID control for accurate control when process conditions change during the culture.

Easy operation

The in-Control has an intuitive touch screen interface for easy operation. It has ethernet communication to SCADA and is applicable through various web browsers and devices, like Windows PC, Apple PC, Linux PC, iPhone, iPad, Android tablet, Android phone.


pH Sensor Traditional electrochemical or Single-use
DO sensor Traditional Polarographic, Optical LumiSens or Single-use
Redox Traditional electrochemical
Temperature Pt-100, measurement Range: 0-150 °C accuracy 0,1°C
Foam/level Resistive based measurement
Weight Input for external balances
Optional Biomass (Capacitance or optical density) or Offgas measurements
Additional I/O Up to 4 Analog in and 4 Analog out, up to 8 Digital out
Actuators (optional)  
Gas External gas box, options for 4 MFC’s or 4 Rotameters
Liquids Using powerbox up to 8 digital outs for switchable pumps,
up to 4 external variable speed pumps
Stirring 0-2000 rpm
Temperature Heating blanket or cooling with cold water water valve
Control Hardware and Software platform Applikon proprietary and Applikon Firmware
Certifications CE certified, GAMP compliant
21 CFR part 11 compatible Yes
Communication & SCADA Lucullus PIMS, DeltaV
  Applikon OPC server available


The Applikon in-Control is ideal for the following applications:

  • Batch, Fed-Batch, Perfusion and Continuous cultivation
  • Microbial and cell culture on lab-scale (up to 7 liter volume)

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