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Getinge Closure Processing System (CPS)

Closure processing system in hospital environment
Closure processing system product photo

Getinge Closure Processing System (CPS)

Clean, sterile, and dry stoppers and closures delivered to the filling machine without breaking containment.

The Getinge Closure Processing System (CPS) provides an unbroken chain of sterility for efficient processing of all types of closures in conjunction with filling lines in pharmaceutical production.


The Getinge Closure Processing System efficiently washes, sterilizes, dries, and delivers all types of closures to isolated or RABS-installed filling lines. The system maintains a constant supply of sterile stoppers and closures while minimizing manual handling and intermediate transfers.

Getinge Closure Processing System (CPS)

Getinge Closure Processing System (CPS)

An unbroken aseptic chain

The CPS from Getinge is a complete integrated system for treatment, storage, distribution, and transfer of stoppers in aseptic production. It minimizes intermediate handling and transfer to maintain sterility and increase integrity control over the aseptic chain. The mobile multi-purpose vessel (MPV) that holds the closures is also used for transportation between the processing unit and the filling machine of the downstream process.

Treatment unit

The MPV is connected to the treatment unit (WSSD) for complete processing of the closures within the vessel by washing, siliconizing, sterilizing, and drying.

Storage and transfer

Transport washed, sterilized, and siliconized (optional step) closures directly to the filling line for aseptic transfer, or store in the MPV until use.

Closure discharge

A lift-and-turn station (LTS) enables the MPV to dock with the filling machine and discharge its load of closures aseptically.

Closure processing system hospital

Complete process capabilities

The complete processing steps in the CPS system includes washing, rinsing, siliconization (optional), sterilization, drying, and cooling. All process steps are carried out in the MPV when it is docked to the treatment unit.

Illustration of closure processing system

Washing, rinsing, and siliconization

Closures in the MPV are subjected to the agitation of sterile filtered air passing through water to fluidize the load during the washing, rinsing and siliconizing (if required) steps. The combination of forceful airflow and constant water overflow moves the closures to ensure continuous removal of particles.

Bottle syringe vial

Adjustable process conditions

The process conditions can be adjusted to suit the particular closure being treated. The closures, vessel and piping system are steam-sterilized using a traditional vacuum steam sterilization process.

Closure processing solution illustration

Drying and cooling

The closures are dried using a combination of heated sterile air and vacuum drying, and are finally cooled using compressed air. Periodic air shocks prevent the closures from clumping. Drying parameters can be adjusted to meet levels required for lyophilized products.

Closure processing system in hospital environment

High-quality construction

The CPS unit uses industry-standard, high-quality non-proprietary components that maximize equipment uptime. The piping is made from sanitary 316L stainless steel. Piping and components are arranged for self-draining to avoid residual water in dead legs.

The MPV is designed with no internal moving parts to avoid particle generation within the load. It is made in 316 L stainless steel with electropolished internal surfaces for sanitary operations. The perforated distribution plate in the bottom of the vessel ensures proper media and air distribution. 


Closure processing

Clean, sterile, and dry closures — particularly rubber stoppers and plungers — are vital components of parenteral packaging. Closures are a functional part of drug administration systems that are in product contact for considerable periods. It is absolutely essential that they are clean and sterile, with due consideration given to their physical, mechanical, and chemical properties.

Discover how to ensure the steady supply of sterile and dry stoppers to your filling line